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The fastest way would be to restart the Wowza server and not reload the cached items at server startup time. I assume that the server restart is something that you would like to avoid.
As you probably are aware, you can purge a specific Item from MediaCache using the Wowza REST API. You can get a list of all the cached assets and you can remove a specific asset from the cache. I will have to test and check with our engineers if it is possible to specify multiple comma separated assets when making the request to the REST API (something like …/flushItemFromCache?filename=http/asset1.mp4,http/asset2.mp4,http/asset3.mp4,…)
I will let you know as soon as I have additional info.
Here is the article showing how you can get a list of all Media Cache cached items and how to remove an item from the local cache, using the Wowza REST API:
https://www.wowza.com/docs/media-cache-query-examples#getassetlist
Zoran
I have just checked with our engineers and it looks like it is not possible to clear all the cached items in one go using a single APi request. There is a product backlog request already created to have this option available, but at this time there is no timeframe set on when this will become available.